Scientists at the University of East Anglia, UK, will investigate the link between sleep disturbances and dementia research at a new state-of-the-art sleep unit.
Sleep disturbances are common in dementia. But it is not yet known whether Alzheimer’s causes sleep problems, or whether sleep problems could be an early predictor of the disease. And now, delving into dementia research, a pioneering investigation at UEA’s new sleep and brain research unit will investigate this big question.
Linking dementia research with sleep disturbances
The research team hope that treating sleep disturbances early on could help slow down the progression of the disease – particularly as there are no other treatments available which do this.
The first study to take place in the unit will investigate whether healthy people who are at increased genetic risk of developing Alzheimer’s could be more vulnerable to sleep loss and how their body clock is affected.
Lead researcher Dr Alpar Lazar, from UEA’s School of Health Sciences, said: “We live in an ageing society, and sleep disturbances and dementia are two significant health problems in older adults.
“A symptom of Alzheimer’s is poor sleep. Good sleep is central to maintaining cognitive performance – such as attention and memory as well as general brain health.
“Sleep deficits have been shown to be early markers in certain brain disorders.
“But is it Alzheimer’s causing sleep problems, or do sleep problems modulate or contribute to the disease process?
“Recent evidence suggest that sleep could be actively involved in the disease process. Trying to identify the cause of early sleep problems in people who have been recently diagnosed or who have genetic predispositions towards Alzheimer’s and the impact of these sleep problems on the brain will help us determine whether improving sleep could potentially slow down the disease process.
Details of the study
Lazar adds: “In this first study, we will look at healthy people who may, or may not, have an increased genetic risk of developing Alzheimer’s disease in the future.
“Volunteers will undertake a screening process, including genetic and psychological testing, wearing a small wrist-worn device to measure sleep and activity at home, and keeping a sleep diary.
“They will then take part in a three-night lab session under one of two conditions –including one-night complete sleep deprivation or taking multiple short naps.
“It may sound gruelling, but we hope it will help us understand more about the links between sleep, the body clock and the genetic risk of Alzheimer’s disease. This will help design future studies investigating specific sleep related interventions that could potentially slow down the progression of the disease.”