Did you know that the opioid crisis is predicted to worsen?

Did you know that the opioid crisis is predicted to worsen?
© iStock/Bastiaan Slabbers

According to the MGH Institute for Technology, USA, the opioid crisis is predicted to get worse, particularly the overdose epidemic.

A study from investigators at the Massachusetts General Hospital (MGH) Institute for Technology Assessment expects that the opioid overdose epidemic in the U.S. is likely to increase in the coming years. Moreover, the measures based on restricting access to prescription opioids will have a minimal impact in reducing overdose deaths.

The research team notes that the varying nature of the opioid crisis, which is now driven by the use of illicit opioids like heroin and fentanyl, has decreased the potential impact of programs targeting prescription opioids.

What do you know about the opioid crisis?

Jagpreet Chhatwal, PhD, of the MGH Institute for Technology Assessment (MGH-ITA), corresponding author of the report explains: “The opioid epidemic started with a sharp increase in opioid prescriptions for pain in the 1990s; but since 2010 the crisis has shifted, with a levelling off of deaths due to prescription opioid overdoses and an increase in overdose deaths due to heroin.”

“In the past five years, deaths have accelerated with the introduction of the powerful synthetic opioid fentanyl into the opioid supply, leading to a continuing increase in overdose deaths at time when the supply of prescription opioids is decreasing.”

The research team used data from sources such as the National Survey on Drug Use and Health and the Centers for Disease Control and Prevention to develop the Opioid Policy Model, reflecting the trajectory of the opioid epidemic in the U.S. from 2002 to 2015. They then used that model to make projections for probable outcomes from 2016 to 2025.

So, what has been predicted?

Under a status quo scenario, in which no further reduction in the misuse of prescription opioids occurs in coming years, the model projects that the annual number of opioid overdose deaths will increase from 33,100 in 2015 to 81,700 in 2025, a 147% increase.

Also, according to the model, during those years, roughly 700,000 people will die from an opioid overdose, 80% from illicit drugs like heroin and fentanyl.

Moreover, the researchers also estimate that by 2025, half of all new opioid users will begin with illicit rather than prescription drugs.

In all scenarios tested, interventions aimed towards reducing misuse of prescription opioids were projected to decrease overdose deaths by only 3 to 5%.

Co-author Marc Larochelle, MD, MPH, of the Grayken Center for Addiction at Boston Medical Center, an assistant professor of Medicine at Boston University School of Medicine, USA, adds: “This study demonstrates that initiatives focused on the prescription opioid supply are insufficient to bend the curve of opioid overdose deaths in the short and medium term.

We need policy, public health and health care delivery efforts to amplify harm reduction efforts and access to evidence-based treatment.”

Chhatwal concludes: “If we rely solely on controlling the supply of prescription opioids, we will fail miserably at stemming the opioid overdose crisis. Illicit opioids now cause the majority of overdose deaths, and such deaths are predicted to increase by 260 percent – from 19,000 to 68,000 – between 2015 and 2025. A multipronged approach – including strategies to identify those with opioid use disorder, improved access to medications like methadone and buprenorphine, and expansion of harm reduction services such as the overdose-reversal drug naloxone – will be required to reduce the rate of opioid overdose deaths.”


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